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29 Sep 2014 - Main.PerryMoerland
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  • AMC coordinator: Dr. Rolf Boot Department of Medical Biochemistry AMC K111, r.g.boot@amc.uva.nl 020-5665157.

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Medical Biochemistry means the chemistry of life in health and disease. In the course “Medical Biochemistry and Medical Molecular Systems Biology”, the teachers will introduce you to a thorough understanding of how molecules take care of all the important chemical and cellular processes that occur during health and disease. The recurrent theme is integration: genetic, signal transduction and metabolic reactions form an integrated complex network of reactions that is at constant steady state (homeostasis) with its environment. Alterations like environmental stress / life style induced perturbations of homeostasis, mutations and polymorphisms in single molecules not only affect single chemical processes but also cellular behavior and can have a severe impact on the proper functioning of complete organs and the organism itself. Thus, studying biochemistry nowadays extends from genetics to genomics, proteomics and gene and protein networks, to metabolic networks of lipids, carbohydrates and proteins, to cellular communication and signaling cascades involved in complex disorders of organs and the cardiovascular circulation. The research tools used in modern biochemistry similarly span a wide range of techniques from genome-wide micro-arrays to metabolic profiling, to mass spectrometry of peptides, proteins and other bio-molecules. In most cases these studies are no longer performed in the test tube, but in complete cells, tissues or organisms, using genetic approaches like viral transductions, RNA-interference and knock-out or transgenic mice. Therefore, we have chosen a format for this course, in which you will cover all the major issues in medical biochemistry both at the textbook level, and at the forefront of biomedical research in a clinical setting. What we hope to accomplish is not for you to memorize detailed knowledge or books by heart, but to come to an integrated insight and understanding of the molecular basis of metabolism and disease processes, which will guide you through the multidisciplinary way in which modern day medical biochemical research is performed.
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Medical Biochemistry means the chemistry of life in health and disease. In the course Medical Biochemistry and Medical Molecular Systems Biology, the teachers will introduce you to a thorough understanding of how molecules take care of all the important chemical and cellular processes that occur during health and disease. The recurrent theme is integration: genetic, signal transduction and metabolic reactions form an integrated complex network of reactions that is at constant steady state (homeostasis) with its environment. Alterations like environmental stress / life style induced perturbations of homeostasis, mutations and polymorphisms in single molecules not only affect single chemical processes but also cellular behavior and can have a severe impact on the proper functioning of complete organs and the organism itself. Thus, studying biochemistry nowadays extends from genetics to genomics, proteomics and gene and protein networks, to metabolic networks of lipids, carbohydrates and proteins, to cellular communication and signaling cascades involved in complex disorders of organs and the cardiovascular circulation. The research tools used in modern biochemistry similarly span a wide range of techniques from genome-wide micro-arrays to metabolic profiling, to mass spectrometry of peptides, proteins and other bio-molecules. In most cases these studies are no longer performed in the test tube, but in complete cells, tissues or organisms, using genetic approaches like viral transductions, RNA-interference and knock-out or transgenic mice. Therefore, we have chosen a format for this course, in which you will cover all the major issues in medical biochemistry both at the textbook level, and at the forefront of biomedical research in a clinical setting. What we hope to accomplish is not for you to memorize detailed knowledge or books by heart, but to come to an integrated insight and understanding of the molecular basis of metabolism and disease processes, which will guide you through the multidisciplinary way in which modern day medical biochemical research is performed.
 


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BMS051: Medical Molecular Systems Biology; “Dealing with stress”
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BMS051: Medical Molecular Systems Biology; Dealing with stress
 

The first part of the course is spent at the Swammerdam Institute of Life Sciences (SILS) of the Science Faculty (FNWI) of the University of Amsterdam. The location is Science Park (SP). In the mornings of the first week we will discuss how biology deals with stressful environments in bacteria, fungi, modelsystems and man. Students are divided in groups of maximally 4 and choose one of the five topics that are discussed in the first week. The topic is turned into a full application according to the guidelines of the Dutch Applied Science Council (STW) during the next 3 weeks. Each topic is introduced in morning lectures. In two afternoon sessions specific tools are discussed in more detail. In the 2nd week microscopy techniques and systems analysis tools are introduced in the mornings. In two afternoon sessions practical aspects are discussed. By the end of the second week students have a good comprehension of ways in which regulation of stress response can be analyzed at various levels of cellular organization.
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10 Oct 2011 - Main.AntoineVanKampen
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  • Week 2 (=week 41) Tools & techniques for molecular systems biology

  • Mo October 11th (van Kampen: AMC / SILS)
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  • Mo October 10th, 2011 (van Kampen: AMC / SILS)
 
  • Morning 11:00-13:00
  • HC: BioInformatics in a medical environment: structuring & analyzing the data deluge

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28 Apr 2011 - Main.AngelaLuijf
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Medical Bioinformatics

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Revision 2
11 Oct 2010 - Main.AntoineVanKampen
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  • HC: BioInformatics in a medical environment: structuring & analyzing the data deluge

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Contact

Antoine van Kampen (a.h.vankampen@amc.uva.nl / 020-5667096 / 06-41768067)
 
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